Oncogene Biology discussion

Evolutionary Developmental Biology - A Reference Guide now available on SpringerLink. Provides an essential resource of knowledge for researchers in evolutionary biology Short Notes on Oncogenes | Gene. Genes that confer the ability to convert cells to a tumourigenic state are called oncogenes. Cancer cells are characterised by immortaliza­tion, transformation and metastasis. Oncogenes induce uncontrolled cell growth resulting in tumour, so it can be anticipated that the products of these genes would act by. More than 30 oncogenes have been identified. A new class of human cancer genes called tumour suppressor genes, growth suppressor genes or and-oncogenes have been identified. 4. Oncogenic Retroviruses: They are responsible for tumours of reticuloendothelial and hematopoietic system (leu­kaemia, lymphoma) or of connective tissue (sarcoma) ADVERTISEMENTS: Read this essay to learn about how oncogenes arise and proteins produced by oncogenes contribute to the development of cancer. 1. Essay on How Cellular Oncogenes Arise: Oncogenes can arise inside cells in two fundamentally different ways. One mechanism involves the participation of cancer viruses that introduce oncogenes into the cells they infect. The [ Cancer arises most often when a series of mutations in proto-oncogenes (causing them to become oncogenes) and tumor suppressor genes results in a cell growing uncontrollably and unchecked. The development of cancer, however, is much easier to understand by looking at the different steps and lack of regulation that occurs over time

Complexity in cancer biology: is systems biology the

ADVERTISEMENTS: In this article we will discuss about:- 1. Cellular Oncogenes Contain Introns 2. Conservation of Proto-Oncogenes during Evolution 3. Proto-Oncogene Products Key Regulators of Cell Division 4. Comparison of Viral Oncogenes with Cellular Proto-Oncogenes 5. Homology with Viral Oncogenes 6. Cancer Cells: Loss of Control of Cell Division. Cancer is a large class of [ Oncogene, genetic material that carries the ability to induce cancer.An oncogene is a sequence of deoxyribonucleic acid that has been altered or mutated from its original form, the proto-oncogene.Operating as a positive growth regulator, the proto-oncogene is involved in promoting the differentiation and proliferation of normal cells.A variety of proto-oncogenes are involved in different.

Building a Model of Tumorigenesis: A small group activity

Springer Developmental Biology - A Reference Guid

Short Notes on Oncogenes Gene - Biology Discussio

Thursday 24 June 2021, 8-9.30 am (EDT), 2-3.30 pm (CET), 8-9.30 pm (CST) Oncogene is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open. Cancer results from alterations in critical regulatory genes that control cell proliferation, differentiation, and survival. Studies of tumor viruses revealed that specific genes (called oncogenes) are capable of inducing cell transformation, thereby providing the first insights into the molecular basis of cancer. However, the majority (approximately 80%) of human cancers are not induced by. This phenomenon, called oncogene addiction, provides a rationale for molecular targeted therapy. The efficacy of this strategy requires novel methods, including integrative genomics and systems biology, to identify the state of oncogene addiction (i.e., the Achilles heel) in specific cancers

Two of the main types of genes that play a role in cancer are oncogenes and tumor suppressor genes. Oncogenes. Proto-oncogenes are genes that normally help cells grow. When a proto-oncogene mutates (changes) or there are too many copies of it, it becomes a bad gene that can become permanently turned on or activated when it is not supposed to be uncle genes are genes that code for proteins that normally direct cell growth they start out as proto-oncogenes and then something happens to convert that proto-oncogene into a full-blown uncle gene an essence some sort of tumor inducing agent or it could also be totally spontaneous now proto-oncogenes code for proteins that help to regulate cell growth and differentiation which makes sense. ADVERTISEMENTS: Read this essay to examine the nature of tumor suppressor genes and the ways in which their loss can lead to cancer. Also learn about the roles played by all the types of gene mutations, along with non-mutational changes, in converting normal cells into cancer cells. 1. Essay on Tumor Suppressor Genes: (Around 4000 [ Oncogenes The homology of viral oncogenes found in tumor-produc-ing RNA viruses (retroviruses) to cellular oncogenes was estab-lished in 1976 by H. E. Varmus, M. Bishop, and colleagues with their work on Rous sarcoma virus and the src gene. It is a mutation or altered expression of these cellular proto-oncogenes oncogenes. 162 By the early 1980s, these suspicions were vindicated: mutant proto-onco- genes were found in human tumor genomes. In each case, a change in the sequence structure of a gene was pin- pointed as being responsible for convert- ing a proto-oncogene into an active on- cogene. Thus, a RAS oncogene in one human bladder carcinoma was.

As noted in the previous section, tumor cells differ from their normal counterparts in many respects: growth control, morphology, cell-to-cell interactions, membrane properties, cytoskeletal structure, protein secretion, and gene expression. We also saw that two broad classes of genes — proto-oncogenes (e.g., ras) and tumor-suppressor genes (e.g., APC) — play a key role in cancer induction Study guide Lecture 3: Tumor viruses part II and Oncogenes 1. Is the Large T antigen an original viral gene, or was it captured from a host cell? Where does it localize within cells, and how can this localization be demonstrated? The Large T antigen are encoded by the virus and is a tumor-associated protein in SV40. o DNA encoding the T antigen has been integrated into the genome and is copied. Humans have an estimated 25,000 protein-encoding genes in their genome. , there is a small subset that seems to be particularly important in the prevention, development, and progression of cancer. These genes have been found to be either malfunctioning or non-functioning in many different kinds of cancer

Oncogenic Virus: Classification and - Biology Discussio

Define oncogene. oncogene synonyms, oncogene pronunciation, oncogene translation, English dictionary definition of oncogene. TEHRAN (FNA)- In a study involving the fruit fly equivalent of an oncogene implicated in many human leukemias, a research team has gained insight into how developing cells The human oral cancer and molecular biology This report delivers a comprehensive genetic alteration profile of lung adenocarcinomas (LADC) driven by ALK, RET, and ROS1 oncogene fusions. These tumors are difficult to study because of their rarity. Each drives only a low percentage of LADCs. Whole-exome sequencing and copy-number variation anal a 25-year-old woman whose mother, aunt, and grandmother had breast cancer. A mutation can cause a change __________. a. in the amino acid sequence of a protein. b. in the shape of a protein. c. in the way the cell cycle is regulated. d. that is beneficial to the cell Targeted therapies for gastrointestinal stromal tumor (GIST) are modestly effective, but GIST cannot be cured with single agent tyrosine kinase inhibitors. In this study, we sought to identify new.

Über 7 Millionen englischsprachige Bücher. Jetzt versandkostenfrei bestellen Oncogenes • The'term'oncogene'was'coined'in'1969'by'R.' Huebner'&'G.'Todaro' • Genes'thathave'the'potential'to'cause. ras p21 was originally discovered as an oncogene product (i.e., the activated form of ras was identified as a transforming gene of an acute transforming murine sarcoma virus). Subsequently, genomic DNA from human tumors and tumor cell lines were demonstrated to contain activated ras genes. Cloning and sequencing of ras oncogenes from acute transforming retroviruses, human tumor DNA, and.

Essay on Oncogenes Cancer Diseases - Biology Discussio

  1. ant gain of function phenotype • Growth Factors, Growth Factor Receptors, G-proteins, Kinases, Gene Regulatory Proteins 10
  2. Oncogenes and Tumor Suppressor Genes. Some types of cancer occur because of mutations in genes that control the cell cycle. Cancer-causing mutations most often occur in two types of regulatory genes, called proto-oncogenes and tumor-suppressor genes. Proto-oncogenes are genes that normally help cells divide
  3. ed the intracellular location of Protein X in cultured cells both before and after exposing the cells to the signaling molecule. The results of the study are shown ____ Oncogenes are genes that can cause tumor formation as a result of a particular m10
  4. Julian Downward. We are investigating how the molecular signals received by cells make them grow and multiply, and how faulty signals lead to cancer. Billions of new cells are made in the body every day, replacing worn-out, dead or damaged cells and keeping us healthy. Cells multiply by dividing - an existing cell splits in half to create two.
  5. g if you don't have a pre-deter

Oncogene: Role in Cancer, Types, and Example

  1. We are a cancer biology lab with a research focus on brain tumors and extrachromosomal oncogene DNA amplification. In particular, we study the process of tumor evolution and therapy resistance. We use high-throughput sequencing, computational analysis and functional studies in our research
  2. An oncogene is a cancer-causing gene that has been mutated. Thus, they are the c) mutated (hyperactive) proliferative genes.. Oncogenes are proto-oncogenes that play a crucial function in cell.
  3. Cancer cells contain multiple genetic and epigenetic abnormalities. Despite this complexity, their growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon, called oncogene addiction, provides a rationale for molecular targeted therapy. The efficacy of this strategy requires novel methods, including integrative genomics and systems biology, to.

Cancer and Genetics of Human - Biology Discussio

Cell Biology and Cancer. Cancers, though studied for decades, continue to amaze researchers with their complexity. This unit reveals new information on normal cell function, proto-oncogenes and tumor suppressor genres, current research in drug design, as well as an overview of tumor biology and angiogenesis. ONLINE TEXTBOOK 22nd Annual Virtual Drug Discovery Summit. July 1-2, 2021 - Virtual event. Presentation: The Biology, Assembly and Catalytic Mechanism of CRL E3 Ligases. Cullgen Speaker: Dr. Yue Xiong. Workshop: E3 Ubiquitin Ligases and Targeted Protein Degradation. Discovery Week - ONLINE. June 1-4, 2021 - Virtual event biotechnology: the use of living organisms (especially microorganisms) in industrial, agricultural, medical, and other technological applications. The study of nucleic acids began with the discovery of DNA, progressed to the study of genes and small fragments, and has now exploded to the field of genomics

Isolation of cancer stem cells from adult glioblastoma

Apoptosis is a normal part of the life cycle of a cell, and it helps your body work efficiently and stay healthy. Scientists are learning more about how apoptosis occurs and is regulated NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine Proto-oncogenes. The genes that code for the positive cell cycle regulators are called proto-oncogenes. Proto-oncogenes are normal genes that, when mutated in certain ways, become oncogenes, genes that cause a cell to become cancerous. Consider what might happen to the cell cycle in a cell with a recently acquired oncogene

Oncogene biology Britannic

Diversity of Retroviral Oncogenes Genetic

ELK (Wuhan) Biotechnology COMolecular heterogeneity of anti-PD-1/PD-L1 immunotherapy

Data-driven discovery of cancer driver genes, including tumor suppressor genes (TSGs) and oncogenes (OGs), is imperative for cancer prevention, diagnosis, and treatment. Although epigenetic alterations are important for tumor initiation and progression, most known driver genes were identified based on genetic alterations alone. Here, we developed an algorithm, DORGE (Discovery of Oncogenes and. Cell 67 (1991): 293-302. CellPress. Hartwell, et al. (1) I am wondering how this research has been developed and expanded upon in relation to cancer biology. (2) I am curious to know if the cell cycle is the same in all organisms, or if there is a substantial difference between human and yeast cell cycles. Goodrich, et al

Wild-type IDH2 promotes the Warburg effect and tumor

What Is an Oncogene? Immunologists Rethink a Fundamental

  1. BI205: Introductory Biology II Week 8 Lab Page 2 of 4 4. What is an oncogene vs. a tumor suppressor? Response: Oncogenes are DNA sequences in genetic material which on stimulation can form a tumor; whereas a tumor suppressor is a protein that is formed by a suppressor gene to suppress the growth of the tumor cells. 5
  2. ant; recessive recessive; haploinsufficient do
  3. Cancer Biology Lab, Bio303, Sp2021 Cancer Biology Case Study In this lab / case study, we will watch a series of videos, complete guided worksheets, and have a class discussion on the various genetic causes of cancer. Much of the material for this activity is provided by the Howard Hughes Medical Institute. Objectives 1. Gain a better understanding of the genetics and mutations involved in.
  4. Mastering Biology Chapter 18. ___________ is the process by which information encoded in DNA is converted to information encoded in RNA. In humans, the hormone testosterone enters cells and binds to specific proteins, which in turn bind to specific sites on the cells' DNA
  5. Biology; Business & Economics Mayo Clinic study suggests patients with lung cancer be screened for MET oncogene Our study suggests that patients with a MET oncogene amplification will not.
  6. What is Developmental Biology? It is the field of biology that studies the processes by which multicellular organisms grow and develop, controlled by their genes. It involves the study of mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, genetic and evolutionary levels

Study Notes on Cancer - Biology Discussio

Proto-oncogenes code for growth stimulating proteins.They are usually positive regulators of the cell cycle. Proto-oncogenes become cancer promoting if they acquire mutations which enable them to. Stem cells in cancer biology. Non-invasive imaging. Key words: Cancer biology, cancer genetics, genomics, computational biology, oncogenes, targeted therapy, functional imaging, stem cells, development. Description of Research Breast cancer is the most common cancer as well as the leading cause of death from cancer among women worldwide

Extrachromosomal DNAs (ecDNAs) are prevalent in human cancers and mediate high oncogene expression through elevated copy number and altered gene regulation[1][1]. Gene expression typically involves distal enhancer DNA elements that contact and activate genes on the same chromosome[2][2],[3][3]. Here we show that ecDNA hubs, comprised of ~10-100 ecDNAs clustered in the nucleus of interphase. Mouse models are critical in pre-clinical studies of cancer therapy, allowing dissection of mechanisms through chemical and genetic manipulations that are not feasible in the clinical setting. In studies of the tumour microenvironment (TME), novel highly multiplexed imaging methods can provide a rich source of information. However, the application of such technologies in mouse tissues is still. All patients with NSCLC with positive oncogene mutation (EGFR and ALK) and ≤5 sites of OM will be screened for this study. If eligible, patients will be screened for the study at diagnosis; however, they would undergo randomisation only after a minimum of 2 months and a maximum of 4 months of TKI therapy

divisions, mutations, mutagen, and oncogene. Multiple choice questions and answers on cell membranes and transport MCQ questions PDF covers topics: Active and bulk transport, active transport, endocytosis, exocytosis, pinocytosis, and Where To Download Biology Study Guide Answers Viruses And Bacteria Background: Purely cutaneous Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative disorder limited to the skin. To date, its pathogenesis remains unclear. Owing to recent findings of specific mutations in the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway in histiocytic proliferative disorders, it provides a novel perspective on the. In a study on cell division, researchers culture synchronously dividing human cells with thymidine. p53, p21, and CHK2 are negative cell cycle regulators, whereas Cdks are proto-oncogenes, which if mutated to be always on could cause cancer. p53, p21, and CHK2 suppress the proteins that regulate the cell cycle, whereas Rb is considered a.

In order to study these important properties of Vpr, we created a recombinant adenovirus H5.010CMV-vpr (adCMV-vpr) as a tool to deliver the vpr gene to various cell lines to examine its biology The proto-oncogene c-sis is the gene for one form of platelet-derived growth factor. The oncogene, v-sis, causes fibroblasts to proliferate because, whereas the normal cellular sis gene, c-sis, is repressed in fibroblasts, the viral copy, v-sis, is under the control of the active viral regulatory region and is highly expressed. Thus, the cell.

The RAS oncogene is the most frequently mutated oncogene in human cancer. It encodes a GTP-binding protein Ras that functions as an on-off 'switch' for a number of key signalling pathways controlling cellular proliferation. Biology of cancer, 1st ed. Garland Science, 2007. The retinoblastoma (Rb) protein is a tumour suppressor gene that. Abstract. Oncogenes are activated through well-known chromosomal alterations such as gene fusion, translocation, and focal amplification. In light of recent evidence that the control of key genes depends on chromosome structures called insulated neighborhoods, we investigated whether proto-oncogenes occur within these structures and whether oncogene activation can occur via disruption of. Status update for a nasty oncogene: It's complicated. Medulloblastoma is a brain tumor located in the cerebellum—the lower portion of the brain at the base of the skull. It is the most common malignant brain tumor of childhood and accounts for about 20 percent of all childhood brain tumors. Image of cerebellum section by Antoine Forget, PhD Arnold M. Schwartz, M. Katayoon Rezaei, in Clinical Respiratory Medicine (Fourth Edition), 2012 KRAS Oncogene. KRAS is an oncogene found on the short arm of chromosome 12 (12p) and shows mutations in approximately 20% of non-small cell lung cancers and amplification of the gene in a smaller set of cancers. The p21 protein (i.e., K-RAS), encoded by KRAS, couples with a cytoplasmic GTPase to. Other articles where RAS oncogene is discussed: oncogene: , MYC and RAS). The origin or location of the gene is indicated by the prefix of v- for virus or c- for cell or chromosome; additional prefixes, suffixes, and superscripts provide further delineation. More than 70 human oncogenes have been identified. Breast cancer has been linked t

Oncogene - Natur

  1. Given that the state of HER2 oncogene amplification has important clinical and therapeutic implications for a condition as prevalent as breast cancer, the purpose of this study was to evaluate the status of HER2 oncogene amplification by IHC and FISH in samples from Colombian patients
  2. g growth factor α (TGFα) ErbB2 has no known direct activating ligand, and may be in an activated state constitutively or become active upon heterodimerization with other family members such as EGFR
  3. Cancer results from a gene that is not normally expressed in a cell, but is switched on and expressed at high levels due to mutations or alterations in gene regulation. Alterations in histone acetylation, activation of transcription factors, increased RNA stability, increased translational control, and protein modification are all observed in.
  4. These genes code for proteins that help regulate cell growth. These important genes are called proto-oncogenes. A change in the DNA sequence of the proto-oncogene gives rise to an oncogene, which.
  5. Presence of these oncogenes are the reason why organisms such as humans develop cancer cells. Become a member and unlock all Study Answers Try it risk-free for 30 day
  6. You'll learn about proto-oncogenes, oncogenes, tumor suppressor genes, viral oncogenesis, p53, and more. Related to this Question. CLEP Biology: Study Guide & Test Pre
  7. ing the personal social and economic consequences of this disease and then we focus on the cellular and molecular biology of cancer. Specifically we study the nature of cancer the role of viruses in cancer cellular oncogenes cellular signaling mechanisms tumor.

Cancer biology 1. Cancer Biochemistry 2. Specific learning objectives 1. List the biochemical alterations in cancer cells 2. Explain what are protooncogenes? 3. Explain mechanisms by which they are activated to cancer-producing oncogenes. 4. List the tumor suppressor gene. 5. Explain the mechanism of action of p53 gene product 6 c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor

Antivaxxers misrepresent a study to falsely claim that COVID-19 vaccines cause cancer. The latest antivaccine propaganda claims that a 2018 research paper published by researchers at Memorial Sloan-Kettering Cancer Center shows that the RNA in the Moderna and Pfizer COVID-19 vaccines can cause cancer The study authors cautioned that the current work was a feasibility study and that more research is needed. We have to see if the analysis of single cells can influence clinical decision making, said Dr. Lohr. And we have to figure out if the information gleaned from single cells can help us understand the mechanisms of resistance The lung cancer study defines the process. Researchers discovered that PKCiota and a second oncogene, SOX2, found in the same region of chromosome 3 known as 3q26, are both amplified and overexpressed in a majority of lung squamous cell carcinomas. The study also shows that these two oncogenes are also functionally linked in these tumors The constitutively active tyrosine-kinase BCR/ABL1 oncogene plays a key role in human chronic myeloid leukemia development and disease maintenance, and determines most of the features of this leukemia. For this reason, tyrosine-kinase inhibitors are the first-line treatment, offering most patients a life expectancy like that of an equivalent healthy person. However, since the oncogene stays. Biological factors - Viral oncogenes, proto-oncogenes and cellular oncogenes; The above factors are called carcinogens. Diagnosis of Cancer. The detection and diagnosis of cancer are very important before it spreads to other parts of the body. Identification of cancer genes is pivotal to prevent cancer. The following methods are used to.

Biology_ Study Guide.pdf - SEMESTER 2 CELLULAR REPRODUCTION The cell cycle G1 Cell growth S DNA Replication G2 Check to see if DNA replication occurred normal genes with the potential to become oncogenes-Oncogenes - gene that has the capability of causing cancer-A mutation in a proto oncogene might result in a oncogene-Tumor suppressor. Author summary Cancer development and progression is associated with accumulation of mutations. However, only a small fraction of mutations identified in a patient is responsible for cellular transformations leading to cancer. These so-called drivers characterize molecular profiles of tumors and could be helpful in predicting clinical outcomes for the patients Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to. OncClub: Join the Chat on Trending Trials in Cancer BCMA as a Target in Heavily Pretreated Multiple Myeloma Expanding Treatment Options for HER2+ Breast Cancer Learn more about new clinical data.

Oncogenes - The Cell - NCBI Bookshel

The study section specifically focuses on regulation of gene expression by tumor suppressors, oncogenes, non-coding RNAs, epigenetics, and stress. The proposals may employ cell models, simple model organisms, animal models or human cancer specimens Carcinoma of the breast and ovary account for one-third of all cancers occurring in women and together are responsible for approximately one-quarter of cancer-related deaths in females. The HER-2/neu proto-oncogene is amplified in 25 to 30 percent of human primary breast cancers and this alteration is associated with disease behavior. In this report, several similarities were found in the.

Oncogene addiction - PubMe

  1. ished cell proliferation and increased apoptosis occur before cystic dysplasia in the renal primordia of Lrp6-deficient mouse embryos. The expression of Ret proto-oncogene (Ret), a critical receptor for the growth factor glial cell line-derived neurotrophic factor (GDNF), which is required for early.
  2. Proto-Oncogenes: Proto-oncogenes are genes that promote cell division in a regulated fashion. If they become activated beyond normal levels, they will turn into oncogenes which lead to cancer
  3. The details of this process were the topic of the new study. How oncogenes simultaneously promote cell death and cell proliferation has been controversial, says Yoo. More in Biology
  4. Michael Anissimov Date: June 28, 2021 Botony is a branch of biology that focuses on plant life.. Biology is, quite simply, the scientific exploration and study of life. At the highest level, it includes categories based on the type of organism studied: zoology, botany, and microbiology.Each field has contributed to humanity in numerous ways such as improvements in agriculture, greater.

Oncogenes and tumor suppressor genes American Cancer Societ

Oncogene-induced senescence (OIS) is a cellular response that limits the replication of cells expressing oncogenes. As a result, OIS is a potent tumor suppressor mechanism limiting cancer progression. Here we describe IMR90 ER:RAS, a widely used model to study OIS in cell culture Oncogenes are genes that have been activated in a way that promotes cell division. Before they are activated, they are called proto-oncogenes. SAT Subject Test Biology: Practice and Study Guid Learn AP Biology using videos, articles, and AP-aligned multiple choice question practice. Review the fundamentals of biochemistry, cell biology, genetics, evolution, and ecology, and develop scientific thinking skills as you explore the study of life

Oncogenes (video) Gene control Khan Academ

The increased activation of a key oncogene in head and neck cancers could be the result of mutation and dysfunction of regulatory proteins that are supposed to keep the gene, which has the. ROS1 is a receptor tyrosine kinase (encoded by the gene ROS1) with structural similarity to the anaplastic lymphoma kinase (ALK) protein; it is encoded by the c-ros oncogene and was first identified in 1986. The exact role of the ROS1 protein in normal development, as well as its normal physiologic ligand, have not been defined. Nonetheless, as gene rearrangement events involving ROS1 have.

Diseases Biology - Biology Discussio

A point mutation is a change in one or a few nitrogenous bases at one location along a DNA sequence. Base substitutions are point mutations where one base is swapped for another. Insertions are. Cell Cycle and Cancer (unit 6B) 1.6.U1 Mitosis is division of the nucleus into two genetically identical daughter nuclei. State the function of mitosis. List four processes which involve mitosis. State the names of the four phases of mitosis. Draw typical eukaryotic cells as they would appear during the interphase and the four phases of mitosis

The Protein Tyrosine Phosphatase PTP-BL Associates withLymphoma transformation of tumor infiltrating lymphocytesCCR7 Regulates Cell Migration and Invasion through JAK2